Achieved | Achievement | % of players | Unlock date |
|---|---|---|---|
 | Easy Beat the game on Easy setting | 94.64% | |
 | Zombie Zapper Kill 200 Zombies in combat | 40.62% | |
 | Medium Beat the game on Medium setting | 35.3% | |
 | Hard Beat the game on Hard setting | 21.63% | |
| Bleedin' Take 200 points of physical damage | 21.54% | |
 | Trap Trickster Use items to bypass 50 traps | 19.25% | |
| Rat Remover Kill 50 Rats in combat | 19.11% | |
| Slime Slapper Kill 10 Slimes in combat | 16.74% | |
| Chaos Crusher Kill 100 Agents in combat | 16.01% | |
| Glowin' Take 250 points of radiation damage | 15.74% | |
| Mutant Masher Kill 50 Mutants in combat | 13.01% | |
| Turnin' Take 100 points of venom damage | 12.38% | |
| Monster Massacre Kill 1000 monsters in combat | 12.14% | |
| Meat Murderer Kill the Meat Machine 25 times in combat | 8.58% | |
 | Death and Glory Discover all 9 Outcomes | 8.35% | |
| Darkness Destroyer Kill Darkness 25 times on any difficulty | 7.78% | |
| Fisto Punch Darkness... Right in the face | 7.61% | |
| The New York Chainsaw Massacre Kill 2000 enemies in combat | 6.33% | |
 | Chain of Skulls Kill one of every enemy type in a single game | 6.12% | |
| Don't bring a Chainsaw to a Knife fight Have your Chainsaw destroyed while having the Knife still in your inventory | 5.94% | |
| Just in Slime Find a way to use Time Grenades on the Slime in the second deck to send it back in time | 4.84% | |
| Seems Ironic Kill the Suicide Cultist with the Implosion Vest | 4.34% | |
| Throne of skulls Kill one of every enemy type in a single game on Classic difficulty | 2.98% |